Analysis of the single domain Antibodies pipeline

Nanobodies from LaMice - llama IgH-transgenic mice

Machine learning approaches to build better synthetic nanobody libraries

NanoLogix: an open-source pipeline to turbocharge nanobody discovery with high-throughput sequencing

INspire – A Novel Intracellular Delivery Platform for Protein-Based Therapeutics

Specific proteolysis mediated by a p97-directed proteolysis-targeting chimera (PROTAC)

Sponsored talk 1 Hybrigenics

Phage and Yeast united for the better: Synthetic Nanobody^® selection and optimization

AbNatiV: VQ-VAE-based assessment of antibody and nanobody nativeness for engineering, selection, and computational design

Effective Nanobodies to fight scorpion stings: Pharmacological and Structural Basis

From llama to nanobody: a streamlined workflow for the generation of functionalised VHHs

A machine learning-driven approach for the multiparametric lead optimisation of Nanobody-based T-cell engagers

Machine learning via sequence diversification for co-optimisation of NANOBODY^® properties

Directional sandwich panning in solution  to select inhibitory Nanobodies against fragile enzymes

Nanobodies against malaria parasite adhesins that block invasion

Structural Insights Leading to Enhanced Breadth and Potency: Unraveling the Potential of a Trimer Dimer-Forming VHH as a Sarbecovirus Therapeutic

Next-generation oncolytic virus with conditional nanobody-based tumor targeting and checkpoint blockade delivery

 An alpaca-derived nanobody protects from lethal Beta and Omicron SARS-CoV-2 infection

A Tiny Skate-derived Nanobody

Optimization of a VHH targeting Tau nucleation core and inhibiting Tau seeding

A biosensor-based phage display selection method for automated, high-throughput Nanobody discovery

Anti-LexA Nanobodies Suppress the Bacterial SOS Response: From Hits Discovery to Structure-Based Engineering

Deep mutational engineering to adapt SARS-CoV-2 specific nanobodies to mutations in emerging Omicron strains

Targeting of tau protein using anti-PHF6 VHH: intrabody or minibody approaches

Selection and characterization of a single domain antibody inhibiting tau neuronal internalization

Intracellular Nanobody Modulates Opioid Receptor Activity

Dynamic study of alpha7 (α7) nicotinic acetylcholine receptor by optopharmacology

Nanobody-Based Sandwich Immunoassay for Pathogenic Escherichia coli F17 Strain Detection

Synthetic Nanobody-based capture assay for rapid detection of Staphylococcus aureus infections

LuLISA: when bioluminescence empowers V_HH-based immuno-assays for human diagnostics from allergy to COVID-19

Novel uPAR-targeting fluorescent single-domain antibodies as tools for in vivo optical cancer imaging

Transfection of mRNA encoding chromobodies: a versatile approach for tracking endogenous nuclear proteins in live cells

The Synthetic library approach to achieve selectivity of sensors or inhibitors : exemplification when targeting highly conserved family of GTPase or Serine Protease

Dynamics of the immune humoral response against SARS-CoV2 between infection and vaccination on a national scale survey

Molecular characterisation and diagnostic development for Oropouche fever, a neglected tropical viral disease

Immunogenicity of nanobodies: Sequence humanisation reduces T cell priming of a anti-SARS-CoV-2-RBD nanobody in humans

Targeting cytidine deaminase with intracellular nanobody-based degraders to defeat resistance to treatment in pancreatic cancer

A biparatopic nanobody with broad neutralisation against SARS CoV-2 variants of concern

Nanobodies against the mitochondrial fission protein Drp1

Targeting PTEN tumour suppressor using nanobodies

ABCD Antibodies: one database to list them all

Nanobodies to inhibit malaria parasite fertilization and development in mosquitoes

Discovery of a new versatile E3 ligase for intracellular antibody-based degraders 

Single domain intrabodies specifically targeting the follicle-stimulating hormone receptor (FSHR) affect receptor signalling and trafficking

A dual targeting CD33/CD123 NANOBODY^® T-cell engager with potent anti-AML activity and a manageable safety profile

A new generation of galectin inhibitors for cancer treatment

New antivirals against human parainfluenza virus

Nanobodies anti-CD98hc: Strategy against non-small cell lung cancer

Nanobody-mediated Modulation of the MAIT cell-MR1 immune axis

Increase of plasma Factor VII(a) levels by Nanobody^® molecules

Software solution to deeply screen and select single-domain antibodies

Targeting multidrug-resistant Acinetobacter baumannii to develop next-generation antibiotics

Nanobody-based synthetic anti-exhaustion modulators for enhanced T cell-based immunotherapies

Unlocking the Potential of Nanobodies: Immunotagging for Targeted Therapy

Nanobody-targeted nanoparticle drug conjugates from protein-based biopolymers

Discovery of CD33 and GPC3 targeted VHHs and their application in CART therapies against AML and HCC

VHHs in targeted photodynamic therapy... and beyond

A Pipeline for Production of Nanobody Repertoires with Diagnostic and Therapeutic Potential

Single-domain antibodies based FGFR4-CAR T cells for treatment of pediatric rhabdomyosarcoma

Self-amplifying RNA vectors encoding PD-1/PD-L1 blocking nanobodies or immunocytokines induce potent antitumor responses

Targeting of TSLP and IL-13 by the novel NANOBODY® molecule SAR443765 reduces FeNO in asthma following single dose exposure

Generation of a Nanobody-based CAR-T Cell Platform

Sponsored talk 2 Fidabio
Structural and functional characterization of nanobodies with Flow Induced Dispersion Analysis (FIDA)

Tackling SARS-Coronaviruses with single-domain antibodies

Two birds with one stone: human SIRPα nanobodies for functional modulation and in vivo imaging of myeloid cells

Making the effect visible - Nanobodies for visualization of the T cell activation status

Development and evaluation of nanobody tracers for non-invasive nuclear imaging of the next-generation immune checkpoint TIGIT

Development of a nanobody-based immunotracer targeting human CD8+ cytotoxic T cells through recognition of the CD8b chain

Characterization of CD163-specific nanobody-based immunotracers for non-invasive imaging of immunosuppressive macrophages

Improvement of histopathological diagnostics using non-destructive 3D histopathology and nanobody technology

SpyDirect enables autocatalytic and high-density nanobody functionalization for bioelectronic protein sensing

Sponsored talk 3 Fox Biosystems
Using FO-SPR to select for single domain antibodies in phage display

Use of Tau-specific Single domain antibodies to inhibit Tau aggregation nucleation and seeding in neurodegenerative diseases

Single domain antibodies as novel therapeutic agents for brain diseases

Nanobody-based immunotherapy for depression

Generation and structural characterization of nanobodies targeting and potentiating the brain alpha7 nicotinic receptor

AAV-based delivery of anti-BACE1 VHH alleviates pathology in an Alzheimer disease mouse model

Single-domain antibodies for studying and manipulating neuronal function

A versatile synaptotagmin-1 nanobody provides perturbation-free live synaptic imaging and low linkage-error in super-resolution microscopy

Increasing brain half-life of biologicals

Using nanobodies to improve drug delivery across the blood-brain barrier

Sponsored talk 4 Preclinics
Beacies, the new web platform for your single-domain antibody probe

Nanobody-based antibody recruiting molecules: Retargeting polyclonal antibodies to CD38 for the killing of multiple myeloma

Cross-neutralizing single-domain antibodies to fight Morbilliviruses

Discovery of AAV-specific nanobodies from LaMice

Discovery and Characterization of Anti-LexA Nanobodies by Yeast Surface Display

Mouse IgG2c-specific and anti-idiotypic nanobodies from LaMice

Streamlining the generation and selection of nano-bodies using a combination of Uloop cloning bacterial Display and density gradient selection

VHHs for sequestering endogenous BMP7 for cartilage regeneration

Generation of single-domain antibodies specific for CD169 that do not interfere with its sialic-acid binding function

Supercharged Nanobodies for Enhancing Cell Penetration and Intracellular Protein Interactions

Engineering Nanobody-Based Conformational Switches for Biotechnological Applications

Insertion of membrane protein-specific nanobodies into the capsid of AAV gene therapy vectors improves transduction specificity and efficacy

Discovery and Engineering of Nanobodies-based Binders for a Novel Therapeutic Approach to SARS-CoV-2

Nanobodies production in mammalian cells: transfection method optimization using a novel and low-cost transfection reagent

Transgenic LaMice as a platform for the discovery of nanobodies

DNA-nanobody conjugates to interrogate and manipulate immune cell interfaces

Unlocking the Potential of VHHs: Structural Characterization of VHH-HLA/Peptide Complex Interactions for Targeting Intracellular Cancer Markers

Targeting ionotropic glutamate receptors with synthetic Nanobodies

Discovery of GSEC-APP complex stabilizers – providing mechanistic insights into Alzheimer's disease

Nanobodies as subtype-specific ligands and allosteric modulators of nicotinic acetylcholine receptors

Evaluation of anti-ricin bispecific single-domain antibodies for therapeutic and diagnostic applications

Influence of NANOBODY^® drug size and blood half-life on solid tumor penetration.

Nanobody 2F8-based PNA-mediated Pre-targeting for the treatment of multiple myeloma

Ultrapotent SARS coronavirus-neutralizing single-domain antibodies that bind a conserved membrane proximal epitope of the spike

Developing Theranostic Nanobodies Against FAP for Cancer Imaging and Therapy

Adding An Additional Dimension to Routine Clinical Diagnostics
Development of Nanobody-based 3D Imaging for Histopathological Analyses

Development of a VHH-nanobodies based ELISA test for human Norovirus detection

Neutralizing Nanobodies against Hantavirus

In vivo biotinylated anti-Microcystin Nanobody as a versatile reagent for the evaluation of fish contamination

Single-domain antibodies against the Plasmodium falciparum circumsporozoite protein demonstrate that the alpha-epitope is exposed and accessible on the surface of malaria midgut sporozoites

Characterization of nanobodies targeting ß-arrestins

Dissecting MAVS signalosomes assembly and degradation using camelid nanobodies

Selection and Characterization of anti-Dengue Virus Nanobodies from a Yeast-Surface-Display Library

Meet the new NABOR: An open access collection of neuroscience focused antibodies

NLRP1 FIIND nanobodies activate inflammasome assembly

Single-Domain Antibodies to Probe the Function of Viral Proteins

Single domain antibody-based immunoassay for the standardization of Clostridium chauvoei vaccine production

Enhancing the immunogenicity of recombinant antigens by their fusion to an anti-CR4 single domain antibody

Trypanothione reductase inhibition by single-domain antibody: relevance on drug development for leishmaniasis

Versatile nanobody platform: Development of bivalent nanobodies to prevent pollen allergy

Nanobody-based IgM heavy-chain antibodies for targeting plasmocytoma and multiple myeloma cells

Utilizing a novel nanobody CAR-T cell platform to identify new resistance mechanisms in CAR-T cell therapy 

Characterization of a nanobody against mesothelin: a new way to detect/defeat Mesothelioma

Anti-MIF nanobodies as a novel tool to improve cancer therapy

V_HH half-life extension strategies and valency: a distribution study in 3D in vitro spheroids

Inhibiting the inhibitor: development of nanobodies to block SERPINB3 in dysregulated hepatic context

A new generation of two-wheel drives for the treatment of multiple myeloma: Nanobody-based biparatopic CD38-specific CAR-NK cells

In vitro characterisation of a Nanobody selectively inhibiting human Neutrophil elastase

Protein Production in Pichia: a toolbox for High yield and Low O-glycosylation

A nanobody-based approach to target CD301b+ dendritic cells in the lung adenocarcinoma

Conformational sensitive, nanobody-based biosensors to detect GPCR activity in living cells

Using competitive, connective, and allosteric Nanobodies to study the interactions between SOS1 and RAS

Antagonistic nanobodies reveal mechanism of GSDMD pore formation and unexpected therapeutic potential

Blocking malaria parasite transmission with nanobodies

Sponsored talk 5 Protein tech
Enhance your Immunoprecipitation and immunofluorescence experiments with nanobodies

Cryo-EM structures of type IV pili complexed with nanobodies reveal immune escape mechanisms

Potent neutralization of Canine Distemper Virus by simultaneously targeting two vulnerable epitopes on the attachment protein

Broadly reactive camel-human homodimeric antibodies provide protection against SARS-CoV-2 variants of concern in a hamster infection model

Nanobody-mediated capture of pathogenic E. coli - a journey through the sugar jungle